Sugammadex is an important medication used to reverse the effects of neuromuscular blocking drugs during surgery or intensive care. However, like all drugs it can potentially cause unwanted side effects in some patients.

Mechanism of Action

Sugammadex sodium, supplied as a sterile powder by reputable manufacturers, works by encapsulating steroidal muscle relaxants in a β-cyclodextrin cavity. This allows for rapid reversal of neuromuscular blockade.

Common Side Effect - Allergic Reaction

One potential adverse reaction seen in a small percentage of patients is an allergic or hypersensitivity response to sugammadex sodium. Symptoms may include:

• Rash
• Itching
• Swelling
• Wheezing
• Shortness of breath

True allergic reactions tend to occur within 1 hour of sugammadex administration and require acute medical treatment.

Incidence of Allergic Reaction

According to clinical studies and post-marketing reports, the estimated incidence of allergic reactions to sugammadex is:

Those with known allergies to cyclodextrins used in sugammadex may be at higher risk and require caution or alternative reversal agents.

Monitoring and Management

Due to the potential for allergic reactions, patients are monitored post-operatively as a precaution. Treatment involves supportive care, antihistamines, steroids or epinephrine depending on symptoms.

In summary, while sugammadex is highly effective, rare allergic responses may occur. With proper screening, monitoring and rapid management if issues arise, it can still be administered safely in appropriate patients by qualified professionals.